Telomere length and cardiovascular diseases
نویسندگان
چکیده
منابع مشابه
Association of Insulin Resistance, Arterial Stiffness and Telomere Length in Adults Free of Cardiovascular Diseases
BACKGROUND Chronic inflammation and oxidative stress might be considered the key mechanisms of aging. Insulin resistance (IR) is a phenomenon related to inflammatory and oxidative stress. We tested the hypothesis that IR may be associated with cellular senescence, as measured by leukocyte telomere length (LTL), and arterial stiffness (core feature of arterial aging), as measured by carotid-femo...
متن کاملTelomere Length and Aging
Telomeres, the TTAGGG tandem repeats at the ends of chromosomes, become progressively shortened with each replication of cultured human somatic cells (reviewed in Wong and Collins (Wong & Collins 2003)) until a critical length is achieved, at which point the cell enters replicative senescence. This situation can be reversed by the enzyme named telomerase that is responsible for Telomere Length ...
متن کاملLeukocyte telomere length and cardiovascular disease in the cardiovascular health study.
The telomere length of replicating somatic cells is inversely correlated with age and has been reported to be associated cross-sectionally with cardiovascular disease (CVD). Leukocyte telomere length, as expressed by mean terminal restriction fragment (TRF) length, was measured in 419 randomly selected participants from the Cardiovascular Health Study, comprising a community-dwelling cohort rec...
متن کاملOriginal Contribution Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
1 Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA. 2 Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, WA. 3 Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, Newark, NJ. 4 Department of Medicine, School of Medicine, University ...
متن کاملTelomere-driven diseases and telomere-targeting therapies
Telomeres, the protective ends of linear chromosomes, shorten throughout an individual's lifetime. Telomere shortening is proposed to be a primary molecular cause of aging. Short telomeres block the proliferative capacity of stem cells, affecting their potential to regenerate tissues, and trigger the development of age-associated diseases. Mutations in telomere maintenance genes are associated ...
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ژورنال
عنوان ژورنال: Complex Issues of Cardiovascular Diseases
سال: 2019
ISSN: 2587-9537,2306-1278
DOI: 10.17802/2306-1278-2018-7-4s-101-107